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However, the rate of sugarCYS metabolite export across our bile duct cancer cell line panel was higher in NRF2 on cells compared with NRF2 off cells, indicating that increased intracellular sugarCYS metabolite levels must result from increased production rather than decreased excretion (Extended Data Fig

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709 These findings underscore the potential of targeting the ACSL4-LOX axis as a therapeutic strategy for diseases associated with ferroptosis

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[Note: Polymorphisms in the genes for CYP enzymes can lead to differences in drug metabolism.] Phagocytosis is the ingestion by receptor-mediated endocytosis of microorganisms, foreign particles, and cellular debris by cells such as neutrophils and macrophages (monocytes)