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Results demonstrated that children with ADHD had lower serum levels of B6, B12 and folate, and also lower levels of homocysteine

Wingert RA, Galloway JL, Barut B, Foott H, Fraenkel P, Axe JL, et al

doi: 10.1126/science.1231143 299 HerrmannJEImuraTSongBQiJAoYNguyenTKet al

There are theories by clinicians that extremely low homocysteine could negatively impact glutathione and detoxification

However, due to the low solubility and high metabolism of naringenin, its bioavailability before entering the systemic circulation is poor, which hinders its clinical efficacy (84)