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Extreme values of pH may also disrupt the tertiary structure of the enzyme, and so distort the active site, or even denature the enzyme protein

investigated de- and remyelination in the cerebellar peduncles in swiss Webster mice exposed to 0.6% (w/w) cuprizone and found an astrocytic expression of IGF-1, whereas IGF-1 receptor (IGF1R) was transiently expressed in OPC (Komoly et al., 1992) during the early recovery phase

It does not keep your longer acting growth signal (called IGF-1) up

For example, MTHFR gene variants and transcobalamin mutations can play a role

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