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The observed differential mRNA and protein expression levels of GPX4 and TfR1 in vitro may bear clinical relevance when considering factors such as tumor heterogeneity and the wide-ranging therapeutic response of thyroid tumors harboring diverse mutational signatures

MussagyCUHuckeHURamosNFRibeiroHFAlvesMBMustafaAet al

Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson's disease in mice

Angiogenesis activation occurs via ROS mediated by hypoxia dependent and independent pathways

We have shown that effective pharmacologic inhibition of GPX4 in PTC cells with direct inhibitor RSL3 induces a robust activation of ferroptosis, increased DNA damage, impaired DNA damage repair response due to reduced p-NPM1 levels, decreased cell viability and cell migration, as well as suppressed spheroid formation and viability in vitro

(March 2014)