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10.1016/j.lfs.2023.122162 476 WangH

A final search of the whole dataset was performed against the new library with a unified global FDR of 1%

These preclinical findings further implicate glucagon activation as the distinguishing factor between incretin receptor mono-, dual-, and triagonists, and they point to unimolecular polypharmacology as an efficient way to target several mechanisms causing obesity

doi: 10.3390/biomedicines11030712

Interestingly, research has shown that even in animals lacking beta-3 adrenergic receptors, acute AOD-9604 administration still increased energy expenditure and fat oxidation, suggesting additional metabolic pathways may be involved beyond the primary beta-3 receptor mechanism

SIRT1 suppresses activator protein-1 transcriptional activity and cyclooxygenase-2 expression in macrophages
