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Various topical formulations of vitamin C with concentration range of 3.75%30% have been considered in melasma, however, in most studies, vitamin C concentration was less than 10% for the purpose of skin photodamage and melasma treatment ( 5.1.11 Glycolic acid Glycolic acid, as an -hydroxy acid (AHA), have a crucial rule in cell-adhesion disruption and further skin desquamation

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Differences in nitric oxide synthase activity in a macrophage-like cell line, RAW264.7 cells, treated with lipopolysaccharide (LPS) in the presence or absence of interferon-gamma (IFN-gamma): possible heterogeneity of iNOS activity