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Abbreviations ACE: angiotensin-converting enzyme ACh: acetylcholine ADMA: asymmetric dimethyl-L-arginine ATII: angiotensin II BH 4 : tetrahydrobiopterin cGKI: cGMP-dependent protein kinase cGMP: cyclic guanosine monophosphate CTP CH-I: GTP cyclohydrolase I DDAH: dimethylarginine dimethylaminohydrolase DETC: diethylthiocarbamate DHFR: dihydrofolate reductase DOCA: deoxycorticosterone acetate eNOS: endothelial nitric oxide synthase FMD: flow-mediated dilation LDL: low-density lipoprotein L-NAME: N G -nitro-L-arginine methyl ester NO: nitric oxide NTG: nitroglycerin ONOO : peroxynitrite PDE1A1: phosphodiesterase 1A1 PKC: protein kinase C PRMT: protein arginine N -methyltransferase ROS: reactive oxygen species sGC: soluble guanylyl cyclase SHR: spontaneously hypertensive rats SNP: sodium nitroprusside SOD: superoxide dismutase STZ: streptozotocin VASP: vasodilator-stimulated phosphoprotein

Chitosan nanoparticles (CN NPs) are particularly efficient delivery vehicles for both peptides as well as for chemotherapeutic drugs that which are used in breast cancer treatment due to their good biocompatibility, susceptibility to enzymatic hydrolysis, and for their high molecular carrying capacity.11 The topo isomerase inhibitor doxorubicin (Adriamycin) is frequently used alone or in combination for the eradication of solid tumors, but a major limitation of this agent is that it also induces non-cancer cell death, thereby resulting in numerous side effects including cardiovascular toxicity

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showed in senescent cells widespread mitochondrial outer membrane permeabilization in part of mitochondria enhanced mtDNA leakage to the cytoplasm and subsequent activation of the cGAS-STING pathway