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Despite their potential to ameliorate neurodegeneration through upregulation of NRF2 and its target genes, as shown by numerous pre-clinical studies, their molecular off-target effects and concomitant unpredictable side-effects pose an obstacle for clinical trials and approval

PMCID: PMC3764612

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MANCARDI D, MEZZANOTTE M

doi: 10.1016/j.coi.2005.07.013

As such, the toxicological assessment by EPA of mercury and derivation of a suitable reference air concentration (RfC) must comply with EPAs (1998) guidance on the assessment of neurotoxins