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However, the crucial role of H 2 S in testosterone biosynthesis has recently been described, the clarification of which could help in the treatment of these disorders associated with low levels of testosterone (58, 61)

Treatment of cells with supplemental iron results in an increase in the HIF hydroxylase activity, while iron chelation produces the opposite effect ( Cultured human cells lacking PCBP1 or PCBP2 exhibit nuclear accumulation of active HIF1, which increases in cells made mildly or transiently iron deficient ( The activity of FIH1, also an iron- and oxygen-dependent HIF1 regulator, is dependent on PCBP1 as well ( Other classes of iron metalloenzymes may also depend on iron delivery by PCBPs

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[DOI] [PMC free article] [PubMed] [Google Scholar] 8.Otzen D., Riek R

5-Fluorouracil (5-FU), which irreversibly inhibits thymidylate synthase, has been widely used for chemotherapy
