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Human evidence: Yes, observational studies exist, though they are older and lack modern control standards

578 Pharmacological treatments include cholinergic agonists, such as bethanechol, to stimulate detrusor muscle contraction, antimuscarinic agents, such as oxybutynin or tolterodine, for overactive bladder symptoms, and beta-3 agonists, such as mirabegron, to relax bladder smooth muscle during the storage phase

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Other reports, however, propose that an increase in plasma or serum MMA during pregnancy is normal and does not reflect a low vitamin B12 status and caution that serum MAA may not be a reliable biomarker of vitamin B12 status among pregnant women (Bae et al., 2015)

Storage Conditions: Laboratory protocols should include regular inspection of storage areas to prevent exposure to extreme temperatures or humidity fluctuations