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Studies have found that HFD can stimulate pro-inflammatory signaling cascades, increase cytokines (TNF-, IL-1, IL-6, and IFN-) that disrupt the barrier, and decrease cytokines (IL-10, IL-17, and IL-22) that promote barrier formation, thereby enhancing intestinal permeability

Telomerase activity diminished and genome oxidation increased in the G1 progeny

Many Nrf2-regulated genes are involved in chemical detoxification and antioxidant defense [76]

We found that MIA3 expression was significantly altered in lung adenocarcinoma (LUAD), breast invasive carcinoma (BRCA), oesophageal cancer (ESCA), gastric and oesophageal cancer (STES), mixed kidney cancer (KIPAN), gastric cancer (STAD), prostate cancer (PRAD), head and neck squamous cell carcinoma (HNSC), clear cell carcinoma of the kidney (KIRC), lung squamous cell carcinoma (LUSC), and hepatocellular carcinoma (LIHC) samples versus control samples

Moreover, HBV-infected HepG2.2.15 showed increased expression of GS, GR and GCL subunits when compared to non-infected HepG2 cells

These two mechanisms are the scientific basis for glutathiones use in skin-lightening products and treatments