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4.2.2.2 Notoginsenoside R1 (NGR1) NGR1 is a novel saponin from Panax notoginseng, a TCM for the adjuvant treatment of DKD (210),which demonstrated that NGR1 treatment increased serum lipids in db/db mice, reduced AGE-induced mitochondrial damage, limited the increase in ROS, reduced apoptosis in HK-2 cells, promoted the expression of nuclear factor erythroid 2-related factor 2(Nrf2) and heme oxygenase-1(HO-1) to abrogate apoptosis-inducing and TGF- signaling by ROS, attenuated histological abnormalities in the kidney, reduced glomerular volume in DKD, inhibited oxidative stress-induced apoptosis and renal fibrosis, and delayed DKD (211)

In another study, we harnessed the potential of an AMPK1 activator, PXL770 and demonstrated its potential to normalize VLCFA levels in cALD and AMN fibroblasts and lymphocytes after a week of treatment

In summary, Current studies suggest that certain monomeric components derived from traditional Chinese herbal medicines may exert protective effects through mechanisms such as modulating gut microbiota, improving the microenvironment, alleviating oxidative stress, and inhibiting ferroptosis

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While several studies cited in this review report favorable safety profiles, including Upadhyay et al

To quantify the proportion of M2 macrophages, cells were stained with APC anti-mouse CD206 antibodies (BioLegend, USA) and PE-Cy7 anti-mouse CD86 antibodies (BD, Cat No