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1 The addition of a catechol-O-methyltransferase (COMT) inhib itor decreases the end-of-dose failure or "wearing off" of L-dopa therapy that causes motor complications

J Biol Chem 283(38):2628326296 Li Y, Jiang D, Liang J, Meltzer EB, Gray A, Miura R, Wogensen L, Yamaguchi Y, Noble PW (2011) Severe lung fibrosis requires an invasive fibroblast phenotype regulated by hyaluronan and CD44

In endothelial cells, DMF upregulates glycolysis and diminishes cellular respiration (oxidative phosphorylation), while it downregulates the serine and glycine biosynthesis pathway by direct inhibition of phosphoglycerate dehydrogenase (PHGDH) activity by a yet unknown mechanism

Plant Foods, Antioxidant Biomarkers, and the Risk of Cardiovascular Disease, Cancer, and Mortality: A Review of the Evidence

On the other hand, aberrant PPP activity in metabolic disorders like diabetes and metabolic syndrome can exacerbate oxidative stress and contribute to disease pathogenesis

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