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Non-small cell lung cancer (NSCLC) accounts for 85% of cases of lung cancer, of which lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) are the most common subtypes

Based on this, Wang et al

Mechanistically, this variant disrupts SP1 transcription factor binding to the JMJD3 promoter, reducing its expression in vascular smooth muscle cells (SMCs)

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10.1016/j.redox.2023.102609

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