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, Brugge, J

Glutathione, a tripeptide naturally produced in the liver from three amino acids, is the bodys most essential antioxidant, and its ability to neutralize free radicals in cells and aid in detoxification processes has highlighted it as a promising therapeutic for a wide range of health conditions, including many challenging neurological conditions.* When a practitioner and a patient consider trying a new therapeutic option like glutathione, one of the first things that comes to mind is the question of potential side effects

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Regarding management, there are several clinical trials that aim to elucidate optimal treatment strategies for steroid-refractory irAEs

As synaptic plasticity is impaired, or otherwise maladaptive, in various neuropsychiatric disorders [182,183] including depression [184], its facilitation by BDNF represents an important potential therapeutic mechanism