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Long-term clinical trials demonstrated modest but statistically significant reductions in HbA1c of 0.3-0.68% when pramlintide was added to optimized insulin therapy, confirming sustained improvement in overall glycemic control

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Clinical trials for semaglutide have shown average weight reductions of 1015% of body weight over time, far surpassing results seen with older prescription diet drugs

In ovariectomy (OVX)-induced osteoporosis in rat and mouse models, liraglutide was administered at doses ranging from ~ 80 nmol/kg/day to ~ 530 nmol/kg/day