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Ultra-processed diet, systemic oxidative stress, and breach of immunologic tolerance

However, owing to the restricted tumor penetration and heterogenous tumor distribution, the antibody squint towards to be localized around tumor vasculature, which limits the efficacy of antibody-based therapies for large tumors

However, cyanide compounds produced during amygdalin decomposition caused important side effects when amygdalin was utilized (236) ( Table 2 )

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These limitations highlight the need for advanced delivery systems such as nano-encapsulation, nano-emulsions, or self-microemulsifying drug delivery systems (SMEDDS) that can protect these compounds from degradation (226228), enhance mucosal absorption, and enable targeted delivery