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As smoking combines (and therefore confounds) an appetitive behavioral habit and a drug, craving for smoking cannot be equated with craving for nicotine

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I suddenly realised that the combination made the magic work and made the drug much, much stronger and more profound

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Identifying these variations can indicate the speed at which an individual will break down cannabis and may provide guidance on an individuals risk of experiencing psychological conditions, such as psychosis, during or after cannabis use

i.e., the 1:2.55 dose equivalence between cannabis joints and tobacco cigarettes for adverse effects on lung function [107]