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This finding was first well established in women who are heterozygous for hypoxanthine phosphoribosyltransferase deficiency, and it has also been observed in several women heterozygous for severely deficient G6PD variants

Machts J, Keute M, Kaufmann J, Schreiber S, Kasper E, Petri S, et al

J Toxicol Clin Toxicol 36, 277285 (1998)

[DOI] [PMC free article] [PubMed] [Google Scholar] 68.Bachman E, Feng R, Travison T, et al

The research showed the behavioral and molecular effects of curcumin on rat models of AD produced by A (A140)

As the transformed cells multiply, they outgrow the diffusion limits of oxygen, thus, becoming hypoxic