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It can involve insulin resistance, higher androgen levels, acne, facial hair growth, irregular ovulation, weight gain, inflammation, cholesterol changes, blood sugar problems, fatty liver risk, and increased cardiovascular risk

The recommended maintenance dosages are 5 mg, 10 mg or 15 mg injected subcutaneously once weekly, the company said

doi: 10.1056/NEJMoa1607141 12 HernandezAFGreenJBJanmohamedSD'AgostinoRBSrGrangerCBJonesNPet al

This appears to be a variant of Pendulum Glucose Control

The meta-analysis identified a nonsignificant increase of 2.4 bpm (95% CI 0.24, 5.05) with GLP-1RA treatment relative to placebo

However, the study cannot exclude a small increase in risk