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In fact, the distal segment of the large intestine can be affected mainly by the circulating components, where both CO and nicotine could modulate the inflammatory profile and leukocyte migration, and the immunomodulatory role would prevail over the impact on the mucosa (Figure 2)

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Participants were 35 non-treatment-seeking male daily smokers of European (80.0%), African (17.1%), and Asian (2.9%) ancestry
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These findings indicate that the process of heating the chemicals in the electronic cigarette liquid causes the formation of the aerosolized carbonyls

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