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In addition, abnormal proliferative hepatocytes and precancerous cells cannot be killed, because of hepatitis viruses-mediated exhaustion of Kupffer cells and hepatic stellate cells (HSCs) and CD4 + T cells by disrupting their MDM2p53 axis

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Senescence regulation by the p53 protein family

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In fact, our aim is that these products, which we call reduced-risk products, will replace cigarettes." Already, PMI has introduced IQOS, a device for smokers that heats tobacco enough to release a nicotine-containing vapor but not enough to cause it to burn and generate smoke