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The main limitation of this study was the lack of consideration of factors that could influence the rate of penetration, such as the anatomical site of application, temperature, humidity, the nature of the vehicle, and the presence or absence of disease

doi: 10.1007/s00281-016-0575-z 202 LindtonBMarklingLRingdnOWestgrenM

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Ferroptosis is this non-apoptotic, peroxidation-driven form of regulated cell death that requires abundant and accessible cellular iron

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These exposures may cause localized inflammation and the release of reactive oxygen species (ROS) within colorectal tissues, which may be causative or promotive of neoplastic processes