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Potential therapeutic targets of anti-HCC There are lots of potential targets that were related with MDM2p53 axis dysfunction that can be considered to exert anti-HCC properties, all of which have been found to be abnormally changed in tissues of HCC patients, and are correlated with favorable/unfavorable HCC outcomes (Table 1)

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Following the removal of duplicates and initial screening of titles and abstracts by two independent reviewers, 14 studies met the eligibility criteria and were included in the final analysis (Figure 1, and Supplementary file: Figure 1, Tables 24)