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The Middle East held one percent

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Mitali Raja, Aarti Garg, Pramod Yadav, Kunal Jha, and Sahil Handa, Diagnostic Methods for Detection of Cotinine Level in Tobacco Users: A Review, 2016

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This phenomenon, called sensitization, involves drug-induced brain changes that may underlie addiction and can be used to identify differences in susceptibility to the effects of drugs

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