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Effects of Nicotine Withdrawal Any of the following are possible withdrawal effects from nicotine: Anxiety Irritability Cravings for nicotine Restlessness or boredom Dizziness (which can last a day or two after quitting) Feelings of frustration, anger, and impatience Depression Trouble concentrating Trouble sleeping Tiredness Chest tightness Slower heart rate Headaches Increased appetite Weight gain Cough, nasal drip, dry mouth, and sore throat Constipation and gas These health effects may appear a few hours after the last cigarette and may prompt a person to continue smoking to alleviate symptoms

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There are concerns that these high nicotine concentrations may lead to greater nicotine dependency

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Abstract Cigarette smoke exposure is a major risk factor for various diseases, and in vitro studies using smoke medium (SM) are crucial for elucidating underlying mechanisms