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In the CNS, nicotine modulates the reward/addiction pathways and cognition through activation of nAChRs in the mesocortical and mesolimbic dopaminergic (DA) pathways ( FIGURE 2 Inhaled nicotine can also have long-term effects on brain development, because nicotinic acetylcholine receptors (nAChRs) play a very important role in modulating the release of neurotransmitters during key stages of neurodevelopment ( e.g

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