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Causes of Vaginal Yeast Infection and Myths Some of the scientifically backed theories about potential causes of yeast infection include: Taking antibiotics that kill helpful bacteria in the vagina and upset the microbial balance High sugar levels in urine resulting from diabetes or kidney damage, not from eating sugar High estrogen levels for example just before menstruation, during pregnancy or HRT therapy Smoking cigarettes or cannabis Clothing that traps moisture including latex or waterproof incontinence underwear and pads or panty liners that trap moisture Diet Myths and Yeast Infection There are a number of diet myths related to the causes of vaginal yeast infection