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[12] Health effects [edit] Even though it is less dangerous than smoking, chewing tobacco is addictive, represents a major health risk, has no safe level of use, and is not a safe substitute for smoking

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Prevalence since time of initiation for adolescents was stable for prescription opioid use disorder and decreased for prescription stimulant use disorder and prescription tranquilizer use disorder, whereas for young adults, prevalence increased for prescription opioid use disorder and was stable for prescription stimulant use disorder and prescription tranquilizer use disorder." Volkow ND, Han B, Einstein EB, Compton WM