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Everyone starts somewhere

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PMID 12640476

While not a perfect translation, this model could be used to represent a lifelong user. The introduction of e-cigarettes might have done a fair job of reducing the incidence of cigarette smoking, but has this come with a cost

The nicotine in these products can disrupt their brain development, negatively impact their learning ability, and amplify their feelings of anxiety and depression

Economic substitutes are important because they may result in a pointless tax