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Smoking affects cells involved in the innate immune response, including antigen-presenting cells (APCs) like dendritic cells, macrophages, and natural killer cells

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The decline was particularly pronounced in high-income countries and regions, such as Australasia (EAPC of 7.42%) and high-income Asia Pacific (EAPC of 6.45%), possibly due to earlier and stricter implementation of tobacco control policies in these areas (22)

Smokers mean (SD) value of daily cigarette consumption was 5.734.88 sticks/day, smoking duration was 2212.63 years, and smoking-initiation age was 18.74.47 years

Smoking can cause the blood vessels, including veins, to constrict, which may decrease blood flow and make them appear smaller

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