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We then evaluated bone mineral density of femurs divided equally longitudinally serially from distal to proximal points in mice representing two time points: (1) after nicotine had been administered for 3 weeks (nicotine), and (2) 2 weeks after nicotine withdrawal (nicotine cessation) (nicotine, n = 6

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33 There is solid evidence from animal studies and in vitro studies that metabolically activated PAH bind to DNA and cause mutations in TP53 and KRAS , as indicated in Figure 1