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During this period, nicotine accumulates in the leaves, peaking when the plant is mature and ready for harvesting

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In low doses, the signs and symptoms of nicotine toxicity are: Nausea, vomiting, salivation Pallor due to peripheral vasoconstriction Weakness Abdominal pain due to peristalsis Diarrhea Dizziness, headache Increased blood pressure, tachycardia Tremors and cold sweats It can also cause an inability to concentrate, confusion, and sensory disturbance

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Frontiers in Psychology (2024)

The present study, as part of the Global Burden of Diseases, Risk Factors, and Injuries Study (GBD) 2020, re-estimated the continuous doseresponse relationships (the mean risk functions and associated uncertainty estimates) between current smoking and 36 health outcomes (Supplementary Table 1) by identifying input studies using a systematic review approach and employing a meta-analytic method 28