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The risk of lung, mouth, throat, pancreas and kidney cancer has decreased

Safety: Adverse-event profiles appear similar across formulations in comparative trials

Recently, European Union has developed a new regulation which implements an upper limit of 20 mg/ml nicotine concentration in liquids that are used with ECs 5

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Finally, it is crucial to address the safety of smoking cessation drugs, specifically varenicline and bupropion, because of the past uncertainties surrounding the cardiovascular safety of these drugs 24