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While aspartic acid replaces asparagine at this position in both IdeS and gasMac-1, the aspartic acid side chain exhibits the same interactions with the equivalent histidine and lysine residues within their respective active sites (Fig

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Abstract Parkinsons disease (PD), the second most common neurodegenerative disorder worldwide, features gradual loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) along with pathological -synuclein (-syn) aggregation

[DOI] [PMC free article] [PubMed] [Google Scholar] 21.Bradford M.A

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