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Its original vision statement was to enhance natural tobacco components that may have potential to either reduce or mitigate the biological activity of tobacco-burning cigarettes.43 This statement was later amended as follows: to provide smokers with products which contain biological activity mitigants.42 Biological activities targeted included reducing nitrosamine levels, nitric oxide levels, carbonyl groups, Ames activity (a measure of mutagenic and carcinogenic potential), ciliostatic and cytotoxic response, and possibly free radical concentrations.44 Numerous RJ Reynolds documents showed that the company considered adding mitigants, such as beta-carotene, to cigarettes.42 , 47 56 Mitigants were defined as antioxidants and other compounds for free radical reduction (i.e., reduction of the concentration of free radicals)57 , 58

In the year 1907 I began to write upon the subject of the wrong and of the injurious effects of tobacco addiction, giving much attention to the members of the clergy and of the medical profession addicted to the use of this drug, holding them to be more responsible for the enslavement of the race than any other class of men, by reason of the elevation of tobacco addiction by these men to the highest points of teaching and example relating to spirituality and to health

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