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The FDA maintains a formal list of Harmful and Potentially Harmful Constituents (HPHCs), and while not exhaustive of every chemical in a puff, it reflects chemicals of highest concern

We should note that the results of an APC analysis of smoking patterns among adults in England indicate that, after adjusting for the period and cohort effect, the odds of being a current smoker decrease after the age of ~ 25 32

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This increased CO emissions result from the herb's lower packaging density and more incomplete combustion

DOI: 10.1002/14651858.CD000031.pub3