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Gastrointestinal Health Problems Linked to Zepbound Use In addition to a heightened risk of pancreatitis and gallstones noted above, some Zepbound patients have also suffered from the following serious gastrointestinal issues: Severe and Prolonged Vomiting While nausea and some vomiting are normal side effects when taking tirzepatide, some patients vomit several times a day for two weeks or more

Feeling cold: Both medications can make you feel colder than usual