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However with effective January 5, 2026 several states have moved to aggressively recalibrate their tobacco taxes

If a higher volume of submissions is received than is currently expected, FDA intends to ensure that entities who submit an adequate plan by the recommended submission date and who work in good faith with FDA to complete its review are not delayed or prevented from distributing or advertising cigarette packages or advertisements due to the agency not having approved their plans by the effective date of the final rule

Many of the discovery efforts have been focused on never-smokers as a way of finding these driver mutations, says Geoffrey Oxnard, a thoracic oncologist at Dana-Farber Cancer Institute in Boston, Massachusetts
