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In its monograph on tobacco smoking, the agency supported this conclusion on the basis of the characteristics of sidestream and mainstream smoke, the absorption of tobacco smoke materials during an involuntary exposure, and the nature of dose-response relationships for carcinogenesis
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In: Phenolic compounds in food and their effects on health, vol

A commentary in The Lancet in 1859 not only discussed the harmfulness of smoking, but also its economic and social toll

As time progressed, we learned more about nicotine as an addictive substance, its ability to create addiction to tobacco products with thousands of dangerous chemicals, and how people may be exposed to these chemicals even if they are nonsmokers
