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A small fraction of nicotine is metabolized to nornicotine (NOR) 13 , which may contribute to the behavioral and enhancing effects of nicotine addiction 25

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Although the true mechanism remains unclear, we posit that arterial stiffness explains the blood pressure subtraction difference from baseline between the hypertensive and nonhypertensive groups 26

Cotinine is one of the predominant metabolites of nicotine

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