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In turn, gene-expression biomarkers measure the amount of messenger RNA (mRNA) codified by genes related to oxidative stress and can provide information on how mechanisms related to synthesis and stability of RNA can be affected by stressors 26

Deeper, more restorative sleep

These antioxidants are involved in adaptation processes that use signals generated by the formation and reaction of free radicals to prevent further oxidant production

Supplementary Table S5)

Strenuous Exercise: Vigorous physical activity can temporarily affect hydration levels, electrolytes, and certain enzyme markers

While the loss of dopaminergic neurons in the substantia nigra remains the hallmark of the disease, growing evidence highlights the significant involvement of other neurotransmitter systems, including noradrenergic, serotonergic, cholinergic, glutamatergic, and GABAergic pathways, in disease progression and symptom variability