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These events preceded the Syndicate, with this new origin retconning the original series run by claiming that the Smoking Man was in fact playing against the Syndicate, despite having previously being seen taking orders from them

The AMA offered a formal resolution in 1998, and the 2009 law giving the FDA authority over cigarettes included the nicotine-reduction strategy as a centerpiece

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Additionally, implementing policies such as tobacco taxes, advertising restrictions, and smoke-free laws creates environments that discourage tobacco use and support cessation efforts

We would like to thank Professor Stanton Glantz, the Academic Editor, and two anonymous reviewers from PLOS ONE for their valuable comments for us to improve this study