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If other smoker reside with you, establish your home as a smoke-free zone

Abbreviations CO carbon monoxide CPD cigarettes per day CReSS Clinical Research Support System DSMB Data Safety and Monitoring Board IRB Institutional Review Board LCMS liquid chromatographymass spectrometry NNAL 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol PI principal investigator REDCap Research Electronic Data Capture SPIRIT Standard Protocol Items: Recommendations for Interventional Trials ST smoking topography VOC volatile organic compound Appendix SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) checklist

The definition of COPD in this study was based on the following question: Has a doctor or other health professional ever told you that you had emphysema/chronic bronchitis/COPD?

This is a scent of soft projection but longevity of easy 10 to 12hrs, if you are expecting it to have loud projection it won't

The first wear we noticed was on the outsole, rather than the upper

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