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A trade publication cites a CNT executive stating that the company is selling highly pure pharmaceutical grade (USP) synthetic S -nicotine, voicing concerns about sales of racemic nicotine mixtures in consumer products.24 Patents assigned to CNT describe a manufacturing process first synthesising racemic nicotine from ethyl nicotinate and n-vinylpyrrolidone nicotinic acid, followed by a stereoselective purification using L-0,0-dibenzoyl tartaric acid.25 26 Another E-liquid ingredient supplies vendor, eLiquiTech (Eldersburg, Maryland, USA), lists the company, Zanoprima Lifesciences (London, UK), as a supplier of synthetic S -nicotine (table 1).27 Zanoprima patented a process involving a biotechnological step for stereoselective synthesis of S -nicotine.28 The start material is myosmine, first stereoselectively converted to S -nornicotine using a commercially available recombinant enzyme, a NADH/NADPH-dependent imine reductase

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