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Another metabolite, Neu5Ac, has been shown to promote endothelial ferroptosis via the SLC3A2 pathway, contributing to endothelial cell injury and accelerating atherosclerotic plaque progression in Apoe-/- mice [112]

Additionally, we examined secretomes from non-cancerous normal cells, such as the keratinocyte-derived epithelial cell line HaCaT, fallopian tube secretory epithelia cells (hTERT FT282), and primary culture of normal skin fibroblasts

Furthermore, phosphorylation of NF-Bp65 acts as an upstream regulator to inhibit ER stress-mediated IEC ferroptosis, thereby alleviating the disease (11)

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Blood 105, 21412145

doi: 10.1021/acs.jafc.2c01335 215 ZhengY.LiY.ZhangY.ZhangR.ZhangY.ZhaoS