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If youre trying to decide between them, youre not alone

For example, a 2024 systematic review and meta-analysis of clinical trials concluded that GLP-1 agonist treatment led to significantly greater improvements on depression rating scale scores compared to control treatments (placebo or other drugs) in adults (Chen et al., 2024)

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Trump said it doesnt have to The Biden administration proposed a rule that would have required state Medicaid programs to cover GLP-1s for obesity treatment, but the Trump administration said it will leave the option up to the states (Scott Olson/Getty Images)

Compounded versions may include additional ingredients: Semaglutide + B12: Combines semaglutide with cyanocobalamin (vitamin B12), often marketed as "semaglutide with B12" or "semaglutide/B12 blend" Tirzepatide + B12: Same concept for tirzepatide Bacteriostatic water vs sterile water: Affects shelf life after reconstitution (28 days vs 7 days) The additional ingredients do not change the core mechanism but may affect tolerability or convenience

Body-image distress is increased in women with polycystic ovary syndrome and mediates depression and anxiety