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Purpose-built for physicians Phentermine may help certain patients lose more weight after discontinuing GLP-1s Key takeaways: Patients on phentermine who gained weight on a GLP-1 had a median 3% weight loss the year after GLP-1 discontinuation
GLP-1 Receptor Agonists (GLP-1 RAs):Primary mechanism: Mimicking the GLP-1 hormone to regulate appetite, blood sugar, and potentially influencing brain reward pathways.Common side effects: Nausea, vomiting, diarrhea, constipation (often gastrointestinal).Potential benefits for mood: Indirect effects through weight management, reduced "food noise," and possible anti-inflammatory actions
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[DOI] [PubMed] [Google Scholar] 112.Jorsal A., Kistorp C., Holmager P., Tougaard R.S., Nielsen R., Hanselmann A
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The side effect profile for cagrilintide dosage with retatrutide combinations is unknown
