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2021;9 doi: 10.3389/fcell.2021.749607

Additionally, if you tolerate 1mg without nausea, constipation, or other gastrointestinal effects, your body has likely adapted and is ready for the next dose tier

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Adequate water intakeoften 80+ ounces dailycombined with fiber supplements becomes essential during weeks 2 through 4 to prevent uncomfortable constipation
