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A daily dose of 14 mg of oral semaglutide for 26 weeks resulted in a mean decline in A1C from baseline of -0.8% (treatment-policy estimand) and -1.0% (trial-product estimand)

in clinical trials it led to a weight loss of 15% to 20% of body weight after 16 months

Evidence for longer-term effects beyond two years was more limited

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But their safety in people with RA hasnt been specifically tested or at least those results havent been presented or published yet, Lane adds

"Comparative Analysis of GLP-1 Receptor Agonists in Weight Management." International Journal of Obesity Research, 2023